Download Advances in lipid research. Vol. 23, 1989 by Rodolfo Paoletti; David Kritchevsky PDF

By Rodolfo Paoletti; David Kritchevsky

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Extra resources for Advances in lipid research. Vol. 23, 1989

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ApoE phenotypes are specified at a single structural gene locus with three alleles: e4, e3, and el. Individuals homozygous for alleles e4, e3, and el have the apoE phenotypes E4/4, E3/3, and El/1, respectively. Individuals heterozygous for apoE alleles have the apoE phenotypes E4/3, E3/2, and E4/2, which correspond to genotypes e4/e3, e3/e2, and e4/e2, respectively. These studies also showed that parents with phenotypes E4/3 and E4/2 (heterozygous for the e4 allele) can produce offspring with the apoE phenotype E4/4.

In addition, suitable genetic markers to assess the contribution of other monogenic hyperlipidemias to the expression of type III HLP are needed. L. apoE ALLELES AFFECT PLASMA LIPID AND LIPOPROTEIN LEVELS IN THE GENERAL POPULATION In addition to the contribution of the apoE phenotype to the expression of type III HLP, Utermann and colleagues originally observed that carriers of the el allele had lower levels of plasma and LDL cholesterol than did those with homozygocity for the e3 allele (Utermann etal, 1979b).

Biochim. Biophys. Acta 638, 347-359.

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