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By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)

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Extra resources for Advances in Topical Antifungal Therapy

Sample text

For the calculation of the aforementioned statistical data the SAS Programme System (Version 5) was available. The statistical evaluation and analysis ofthe study were done at the Institute of Biometry of Bayer AG. The complete data of all 90 patients could be statistically evaluated and processed. There were 54 males and 35 females; in 1 patient this information was missing. The average age of patients, their weight and height as well as the area of mycosis in square centimeters are shown in Table 1.

Our study was therefore aimed at determining whether bifonazole had any anti-inflammatory activity. In an uncontrolled observation study histamine was used to induce an allergic reaction in ten subjects pretreated for 2 h and for 2 and 12 h on 28 cm 2 skin with bifonazole, hydrocortisone and bifonazole basic cream and on an untreated control patch. Wheal and flare sizes were evaluated planimetrically after 15, 30, 60 and 90 min. In the histamine wheal test bifonazole and hydrocortisone showed an anti-inflammatory activity - in particular 15 and 30 min after triggering of the allergic reaction; wheal and flare surfaces were significantly smaller than the areas treated with the basic cream or left untreated.

Wheal and erythema sizes were found to be significantly smaller - especially 15 and 30 min after histamine provocation - in the areas pretreated with bifonazole and 1% hydrocortisone as compared to the areas treated with cream base or left untreated. In the present experimental model the antihistaminergic or anti-inflammatory effect of bifonazole was comparable to that of the hydrocortisone concentration used. Discussion A great number of studies have furnished evidence for the broadspectrum antifungal activity ofbifonazole [1, 2, 3, 9, 10].

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